Sii Pneumosil Drug Interactions

Pneumococcal Polysaccharide Conjugate Vaccine (Adsorbed) (10-valent) can be given with any of the following vaccine antigens, either as monovalent or combination vaccines: diphtheria, tetanus, whole-cell pertussis, Haemophilus influenzae type b, inactivated or oral poliomyelitis, rotavirus, yellow fever, hepatitis B, measles and rubella. Clinical studies demonstrated that the immune responses and the safety profiles of the administered vaccines were unaffected. Studies with other pneumococcal conjugate vaccines co-administered with mumps, varicella, meningococcal ACWY, and rotavirus vaccines have demonstrated that the immune responses of the other pneumococcal conjugate vaccines and the co-administered vaccines were unaffected.
In clinical trials, when other pneumococcal conjugate vaccines were given concomitantly but at a different site/route, with rotavirus vaccine or hepatitis A vaccine, no change in the safety profiles for these infants was observed.
Different injectable vaccines should always be given at different injection-sites. Till date SII PNEUMOSIL (10-valent) clinical studies have been conducted in India and the Gambia in toddlers and infants.
In the Gambia Phase ½ study, there was no evidence that administration of SII PNEUMOSIL (10-valent) interfered with the immune response to any component of co-administered pentavalent vaccine.
In the Gambia Phase 3 study, non-inferiority of the immune responses induced by EPI vaccines between treatment groups was demonstrated for all EPI vaccines co-administered during the 3-dose primary vaccination series (6 weeks, 10 weeks and 14 weeks) - namely, whole-cell pentavalent vaccine (DTwP-HepB-Hib) oral polio vaccine, inactivated polio vaccine, and oral rotavirus vaccine. Standard EPI vaccines based on the Gambian EPI schedule (measles-rubella vaccine and yellow fever virus vaccine) were co-administered with the booster dose of study vaccine. Non-inferiority of the immune responses was demonstrated for these co-administered EPI vaccines. While there are no known published data on co-administration of other pneumococcal conjugate vaccine with yellow fever virus vaccine, the high seroresponse rate to yellow fever in the Pneumococcal Polysaccharide Conjugate Vaccine (Adsorbed) (10-valent) group indicates that Pneumococcal Polysaccharide Conjugate Vaccine (Adsorbed) (10-valent) does not interfere with the immune response to yellow fever virus vaccine.
This section will continue to be updated along with further studies.